Neocutis™

Neocutis S.A. was founded in February 2003 as a spin-off from the Medical School of the University Hospital of Lausanne, Switzerland. It is a privately held specialty bio-pharmaceutical company focused on wound healing, dermatology and skin care.

PSP® - a new skin nutrient

Inspired by fetal skin's unique properties, Neocutis' proprietary technology uses cultured fetal skin cells to obtain an optimal, naturally balanced mixture of skin nutrients including cytokines, growth factors and antioxidants.
This mixture is called PSP®, which stands for 'Processed Skin Cell Proteins'. PSP® production and safety
PSP® is obtained in a biotechnology derived process following stringent manufacturing procedures. A cell bank was established starting with a single skin biopsy of fetal skin tissue. The cell bank is stored frozen in liquid nitrogen and can be kept for many years, thereby providing a sustained supply of cells for PSP® production over decades.

PSP® in cosmetic research
Through years of research, physicians discovered fetal skin has a unique ability to heal wounds without scarring. Inspired by this, medical researchers at the University Hospital of Lausanne, Switzerland created a biotechnology process to extract the rich proteins responsible for scarless wound healing from cultured fetal skin cells. A small biopsy of fetal skin was donated following a one-time medical termination and a dedicated cell bank was established for developing new skin treatments. Originally established for wound healing and burn treatments, today this same cell bank also provides a lasting supply of cells for producing Neocutis' proprietary skin care ingredient Processed Skin Cell Proteins (PSP®). No additional fetal biopsies will ever be required.

The story behind PSP®
Investigating an optimal skin care follow-up regimen after treating burn and ulcer patients with a three-dimensional skin allograft comprising cultured fetal skin cells seeded onto a collagen matrix [23, 24], the research team at University Hospital of Lausanne developed a cosmetic cream containing the cell lysate of the same cultured fetal skin cells as used for the graft preparation. The cell lysate was later called Processed Skin Cell Proteins (PSP®).

As an example, the right Figure illustrates the use of PSP® containing cream to improve texture and appearance of the skin in a woman 65 years of age with a healed leg ulcer. The figure shows the leg after grafting was complete and the wound closed (upper picture), and after the PSP® cream was applied daily for approximately six months (lower picture).

Together with the help of a compression bandage, the follow-up regimen aimed to improve texture and appearance of skin once the wound was closed and had completely healed.

Cosmecueticals

NEOCUTIS CosmecueticalsNEOCUTIS Bio-restorative Skin Cream, JOURNÉE Bio-restorative Day Cream, LUMIÈRE Bio-restorative Eye Cream and BIO-GEL Bio-restorative Hydrogel are the only products to contain PSP®.

Through years of research, physicians discovered fetal skin has a unique ability to heal wounds without scarring. Inspired by this, medical researchers at the University Hospital of Lausanne, Switzerland created a biotechnology process to extract the rich proteins responsible for scarless wound healing from cultured fetal skin cells. A dedicated cell bank was established for developing new skin treatments using a single biopsy of fetal skin. Originally established for wound healing and burn treatments, today this same cell bank also provides a lasting supply of cells for producing NEOCUTIS proprietary skin care ingredient Processed Skin Cell Proteins (PSP®).

PSP® provides the most complete and balanced combination of human growth factors and cytokines currently available.

NEOCUTIS Bio-restorative Skin Cream

NEOCUTIS CosmecueticalsClinically proven to reduce the appearance of facial wrinkles after two months of daily use.

The first and original skin cream formulated with PSP®, the most complete protein blend of Human Growth Factors, Cytokines and Interleukins available to help improve apparance of aged skin and soothe skin.

ANTI-AGING
  • Helps reduce appearance of fine lines and wrinkles.
  • Improves skin texture and tone for renewed radiance.
  • Enhances skin firmness.

POST-PROCEDURE
  • Helps promote recovery and skin restoration after cosmetic or dermatological procedures such as chemical peels, micro-dermabrasion, laser and/or light treatments and cosmetic surgery.

ADJUNCTIVE CARE
  • Helps soothe skin when used in combination with topical medications such as rosacea treatments, anti-acne or retinoids.

BIO-CREAM is ideal for normal to dry skin types.

Use AM/PM or as directed by your physician for renewed skin vitality!
The efficacy of Bio-restorative Skin Cream with PSP® in helping to reduce the signs of facial skin aging was proven in several clinical studies.

The results of the first anti-aging study were published in the Journal of Drugs in Dermatology, February 2007, Volume 6, Issue 2, Pages 197-201. The detailed results of the studies can be found by clicking the links below!

Clinical Data: 2 Month Study
Reduction of Skin Wrinkle Depth

Development of Neocutis Bio-restorative Skin Cream
Neocutis Bio-restorative Skin Cream was developed at the University of Lausanne (Switzerland) based on an in-depth understanding of the nutritive needs of skin.

Composition of Bio-restorative Skin Cream
Bio-restorative Skin Cream is an oil-in-water emulsion designed for optimal efficacy of PSP™. The cream is free of fragrances, color additives and sunscreens, which ensures a good skin tolerability.

Use of Neocutis Bio-restorative Skin Cream
The administration of Neocutis Bio-restorative Skin Cream is typically a two-step process

Additional information about Neocutis Bio-restorative Skin Cream
Note that Neocutis Bio-restorative Skin Cream is for external use only.

Anti-Aging A recent anti-aging study showed that Bio-restorative Skin Cream with PSP® significantly helps to reduce signs of skin aging. PSP® contained in Bio-restorative Skin and Eye Cream helps to improve the appearance of aged skin by providing the most complete and balanced combination of human growth factors and cytokines currently available.

Anti-Aging Study
After only two months of twice daily use of Bio-restorative Skin Cream with PSP™, 83% of subjects showed improved appearance of wrinkles in eye area and 50% of subjects showed improved appearance of wrinkles in mouth area.

Role of PSP® in anti-aging
Recent studies suggest that aged or photoaged skin has the same needs as wounded skin, where growth factors and other cytokines interact synergistically to initiate and coordinate the wound healing response.

Aging of Skin
Human skin, like all other organs, undergoes chronological aging. In addition, unlike most other organs, skin is in direct contact with the environment and therefore ages as a consequence of environmental damage. The primary environmental factor that causes human skin aging is ultraviolet irradiation from the sun. This sun-induced skin aging (called photoaging), like chronological aging, is a cumulative process. Aged and photo-aged skin manifests in fine and deep wrinkles, loss of elasticity, loss of translucency as well as in color and pigmentation changes.

LUMIÈRE Bio-restorative Eye Cream

NEOCUTIS Cosmecueticals Intensive line smoothing eye cream with PSP® helps improve signs of skin in the delicate eye area.

Formulated with 30% more PSP®, a complete protein blend of Human Growth Factors, Cytokines and Interleukins available to smooth and soften the appearance of fine lines and wrinkles.
  • PSP® and hyaluronic acid help firm and hydrate the delicate skin under and around the eyes.
  • Helps reduce the appearance of under eye darkness.
  • Smooths the appearance of fine lines and wrinkles.
  • Caffeine helps alleviate signs of skin puffiness.
  • Soothes and refreshes the delicate eye area to help minimize signs of fatigue.
Apply AM/PM or as directed by physician for visibly younger looking eyes!

Recently, a large clinical study with LUMIÈRE Bio-restorative Eye Cream was completed. The study demonstrated that LUMIÈRE helps to significantly reduce the signs of aged and stressed skin around the eye after six weeks of twice daily use. The results of this study were published in the Journal of Drugs in Dermatology, July 2007, Volume 6, Issue 7, Pages 725-729.

See detailed study results by clicking on link below!
LUMIÈRE Study

What makes LUMIÈRE unique?
Research indicates that PSP® combined with the unique blend of key ingredients contained in LUMIÈRE helps to promote youthful more vibrant skin around and under the eyes.

Use of LUMIÈRE Bio-restorative Eye Cream
Apply a single pump of LUMIÈRE to the freshly cleansed skin area surrounding your eyes morning and night or follow the recommendations of your skin professional.

BIO-GEL Bio-restorative Hydrogel

NEOCUTIS Cosmecueticals Unique Hydrogel combines PSP® and Hydrating Hyaluronic Acid to help restore radiance to aged skin.

Formulated with PSP®, a complete protein blend of Human Growth Factors, Cytokines and Interleukins to help improve signs of aged skin and soothe skin.

ANTI-AGING
  • Helps reduce the appearance of fine lines and wrinkles.
  • Improves skin texture and tone to restore luminosity.
  • Oil-free hydrogel texture is ideal for men.

POST-PROCEDURE
  • Nurtures, nourishes and refreshed stressed looking skin after non-invasive cosmetic procedures such as fillers, micro-dermabrasion and light peels.

BIO-GEL is ideal for normal to oily skin types.
Use AM/PM or as directed by physician to nurture skin.

What makes BIO-GEL unique?
In addition to PSP®, BIO-GEL contains sodium hyaluronan; which is the sodium salt of hyaluronic acid. Sodium hyaluronan is a major, natural component of the extracellular matrix of skin. Sodium hyaluronan in combination with growth factors are described to play a key role in wound healing.

Use of BIO-GEL Bio-restorative Hydrogel
BIO-GEL is suitable for all skin types including oily and problematic skin and was specially developed for day-time use. The formulation is non comedogenic.

JOURNÈE Bio-restorative Day Cream

NEOCUTIS Cosmecueticals The most complete anti-aging day cream with PSP®, anti-oxidants, hyaluronic acid and UVA/UVB protection SPF 30+ to help improve look of aged skin, protect and hydrate skin.

Formulated with PSP®, a complete protein blend of Human Growth Factors, Cytokines and Interleukins to help improve signs of aged skin and soothe skin.
  • Helps smooth the appearance of fine lines and wrinkles.
  • Provides long lasting hydration for radiant, luminous skin.
  • Potent anti-oxidant blend of polyphenol rich green tea extract, stabilized vitamins C and E plus melanin act synergistically to help fight against daily environmental assaults.
  • Fast absorbing, skin-toned, non-greasy formulation blends flawlessly into skin.
JOURNÈE is ideal for all skin types.
Use AM/PM or as directed by physician as a 1 minute complete anti-aging treatment!

What makes JOURNÈE unique?
JOURNÈE simultaneously addresses both, visible signs of chronological and photo-aging or premature skin aging.

Use of JOURNÈE Bio-restorative Day Cream
Apply JOURNÈE in the morning or follow the recommendations of your skin professional. In the evening, use NEOCUTIS Bio-restorative Skin Cream or Bio-Gel Bio-restorative Hydrogel.

PERLE Skin Brightening Cream formulated with Melaplex™

NEOCUTIS Cosmecueticals Illuminate skin with a hydroquinone-free scientific breakthrough to help brighten skin and reveal fewer spots!

Spot minimizing skincare cream with patent pending Melaplex™ helps reduce the appearance of skin discoloration and uneven skin tone. MELAPLEX™, an exclusive skin brightening complex, is a hydroquinone-free alternative which helps improve the appearance of skin discoloration and uneven skin tone.

PERLE SKIN BRIGHTENING CREAM HELPS TO:
  • Visibly diminish the appearance of dark spots and uneven skin tone.
  • Restore the look of skin clarity and tone for a more luminous, younger looking complexion.
  • Continuously improve skin brightness and radiance.
  • Replenish skin's texture with Shea Butter, Jojoba Oil and anti-oxidants C and E.
  • Gentle enough for extended use and suitable for all skin types.

Use AM/PM or as directed by your physician for brilliant skin rejuvenation! Use of JOURNÈE Bio-restorative Day Cream SPF 30+ during the day is recommended.

PÊCHE Redness Control Formulated with ROSAPLEX™

NEOCUTIS Cosmecueticals Serum with patent pending ROSAPLEX™ helps manage skin redness for a more balanced complexion.

ROSAPLEX™ is an exclusive redness balancing complex, fortified with Dextran Sulfate, Zinc, Caffeine and Glycerin to help minimize the appearance of blotchiness, blemishes and improve overall skin tone.

PÊCHE helps to:
  • Visibly diminish the appearance of skin redness for a healthy glow
  • Restore skin's natural moisture balance and helps strengthen the skin
  • Improve the appearance of skin blotchiness
  • Limit the appearance of blemishes
  • Soothe and comfort

PÊCHE can be applied AM/PM as adjunctive skincare along with medication or as a part of a maintenance regimen for the management of skin redness.
Use of JOURNÈE Bio-restorative Day Cream SPF 30+ during the day is recommended.

LUMIÈRE RICHE Bio-restorative Eye Balm with PSP®

NEOCUTIS Cosmecueticals A luxurious, hydration-supplementing formula suitable for dry, dehydrated skin.

The skin rejuvenating action of PSP® technology is combined with super moisturization, caffeine, skin soothing botanicals and wild yam extract to help target the 7 visible signs of premature skin aging:
  • appearance of lines and wrinkles
  • puffiness
  • under eye darkness
  • hydration
  • stress and fatigue
  • sagging and textural changes caused by the environment
  • loss of appearance of elasticity and change of skin tone in relation to seasons or mid-life

Luxuriously rich yet deceptively light, LUMIÈRE RICHE Eye Balm helps increase skins moisture retention. Applied twice daily to the skin around the eye area, eyes will regain their youthful vital look in a few weeks.

HYALIS Refining Serum

NEOCUTIS Cosmecueticals Fast Acting Hydrating serum helps deliver immediate moisture for youthful, radiant looking skin.

Formulated with the highest concentration of pharmaceutical grade 1% Sodium Hyaluronate (Hyaluronic Acid) for maximum purity and efficacy.

ANTI-AGING
  • Help smooth and plump skin to help minimize the signs of skin aging.
  • Intensive hydrating action leaves skin supple and smooth.

POST-PROCEDURE
  • Helps soothe and hydrate stressed, irritated skin.

ADJUNCTIVE CARE
  • Ideal for use as adjunctive care to drying dermatological treatments, such as rosacea, anti-acne and retinoid regimens.

HYALIS is ideal for all skin types.
Use AM/PM and can be incorporated into any skincare regimen.

NEO-CLEANSE Gentle and Exfoliating Skin Cleanser

NEOCUTIS Cosmecueticals Glycerin rich clarifying cleansers help gently melt away make-up and surface impurities as skin is infused with a healthy dose of moisture.

Formulated without harsh sulfate detergents, dyes or fragrances for skin that feels fresh, clean and comfortable after cleansing. Specifically formulated to work together with NEOCUTIS skincare.

GENTLE SKIN CLEANSER
Intolerant or sensitive skin
  • Luxuriously creamy cleanser rich in Glycerin helps gently purify without stripping skin's natural barrier.
  • Skin soothing formula ideal for dry skin, post-procedure cleansing and Rosacea prone skin.

EXFOLIATING SKIN CLEANSER
Normal to oily skin
  • Retexturizing 10% Glycolic Acid gel cleanser helps reveal fresh, vibrant skin that glows with the hydration of Glycerin.
  • Primes skin prior to procedures.

Use AM/PM or as directed by physician to cleanse, hydrate and prime skin.
 
 
 
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